Process and clean the data | Data transformation | Analysis | Fitting marginal (on-axis) data | Optimization algorithms | Custom marginal fit | Compute expected response for off-axis data | (Generalized) Loewe model | Highest Single Agent | Bliss Independence | Alternative Loewe Generalization | Plot 2D cross section of response surface | Statistical testing | meanR | maxR | Effect sizes and confidence interval | Analysis in case of variance heterogeneity | Analysis of multiple experiments

Marginal monotherapy curves | Null models of no synergy | Occupancy | Classical Loewe model | Generalized Loewe model | Highest Single Agent | Bliss independence model | Alternative Loewe Generalization | Calculation procedure | Synergy evaluation assuming equal variances for on- and off-axis points | meanR | maxR | Synergy evaluation in case of variance heterogeneity | Adapted meanR | Adapted maxR | Bootstrapping under unequal variances | Advantages of unequal and model methods compared to assumption of equal variances | Effect size for off-axis points | Confidence interval\label | Standard error\label | Single effect measure | Confidence interval | On resampling residuals\label